Top 12 Venture Capital Firms for B2B Startups To Knw
Searching for VC firms that invest in B2B companies? Here are 12 to know. Once you raise capital, our tools help you put it to work efficiently.
Rho Editorial Team
For founders in the business-to-business space, finding the right investor is about more than just capital. You need a partner who understands the specific challenges and opportunities of selling to other companies, whether you're building enterprise software or a new SaaS tool.
To help you find that fit, our team has curated this overview of top B2B venture capital firms. This guide is designed to help you quickly identify relevant investors before or during your fundraise. Once funding is secured, Rho’s integrated financial tools—including business banking, corporate cards, and automated bill pay—help startups manage and deploy capital efficiently.
Rho provides access to business banking, corporate cards, and bill pay — built for startup teams moving fast.
Key Takeaways
Securing venture funding in the B2B space means finding a partner with deep industry knowledge, not just a source of capital.
Top venture capital firms like Work-Bench, MissionOG, Storm Ventures, and Mighty Capital are notable backers for startups focused on business-to-business products and services.
Once you've secured funding, our team at Rho helps you manage your new capital with integrated business banking, corporate cards, and automated bill pay.
Which VC Firms in B2B Are Right for Your Stage?
Whether your company is in its early stages or preparing for an exit, it helps to know which investors to approach. This overview outlines which B2B venture capital firms invest at each stage to help you focus your fundraising efforts.
Pre-seed and Seed VC Firms in B2B
Pre-seed and seed rounds are the earliest stages of funding, typically used to validate your idea and build a minimum viable product. For founders seeking their first institutional check, B2B-focused VC firms like New York-based Work-Bench, 2048 Ventures, and the accelerator Upekkha are excellent places to start.
Early Stage VC Firms in B2B
Early-stage funding, which includes Series A and Series B rounds, is for companies with proven traction that need capital to scale their team and accelerate growth. Enterprise technology venture capital firms that support this phase include Storm Ventures, MissionOG, and Cervin Ventures, all of which have a history of backing successful SaaS and software companies.
Late Stage VC Firms in B2B
Late-stage rounds provide significant capital to established companies for market expansion, acquisitions, or as a final private round before a potential IPO or M&A. If your company is at this mature phase, you might approach investors like Wildcat or MissionOG, which have experience guiding companies toward major exits.
Once you secure that funding, our team at Rho can help you manage and deploy your new capital with integrated business banking, corporate cards, and automated bill pay.
It's also worth noting that many venture capital firms invest across multiple stages, from seed to growth.
To help you build your list of target investors, here is a more detailed overview of top VC firms in the business-to-business space. We've outlined their investment stages, geographic focus, and what makes each one a compelling choice for founders.
1. Work-Bench
Based in New York City, Work-Bench is a venture capital firm that concentrates on enterprise software, primarily at the seed stage. They provide early backing for companies building technology for other businesses.
The firm is known for its sharp focus on enterprise technology and has backed several unicorns, including digital identity company Socure and mental health platform Spring Health. This track record shows their ability to identify and support high-growth companies in the B2B space.
Work-Bench is a strong potential partner if you are an early-stage founder building enterprise SaaS or software solutions. Their deep network within the NYC tech community is particularly valuable for founders based there.
Investment stages: Seed, Early Stage, and Late Stage Venture
Industries of focus: Enterprise Software, B2B, SaaS, Financial Services
Geographical presence: New York, NY
Founded: 2013
Notable portfolio companies: Socure, Spring Health, Cockroach Labs, VTS
Portfolio size: Over 75 investments
You can refer to their website here.
2. MissionOG
MissionOG provides capital to B2B technology companies, supporting them from early stages through their growth phase. Based in Philadelphia, the firm has a strong focus on businesses building solutions for other companies.
The firm has a clear interest in financial services and B2B software, backing companies like AI fraud-detection platform Featurespace and embedded fintech provider Autobooks. They have experience leading rounds, as seen with iDonate, and have backed companies internationally, such as UK-based Pay4Later.
This firm is a great potential partner if you're a founder in the B2B fintech or risk management space. Their willingness to invest from early to late stages suggests they can be a long-term backer as your company scales.
Investment stages: Early Stage Venture, Late Stage Venture
Industries of focus: B2B, Financial Services
Geographical presence: Philadelphia, PA
Founded: 2012
Notable portfolio companies: Venminder, Pay4Later (now Deko), iDonate, Featurespace, Autobooks
Portfolio size: 68 investments
You can refer to their website here.
3. Storm Ventures
Storm Ventures is a venture capital firm based in Menlo Park that focuses exclusively on early-stage enterprise technology companies. They have a long history of backing B2B startups since their founding in 1997.
The firm is known for its early investments in companies that achieve massive scale, such as Talkdesk, which grew to a $10 billion valuation after Storm's initial Series A backing. Their portfolio also includes major exits like Marketo and Pipedrive, demonstrating a clear strategy of supporting companies toward significant market outcomes.
If you are a founder building an enterprise software company and are looking for a partner with a proven record of scaling B2B businesses, Storm Ventures could be an ideal match. Once funding is secured, our team at Rho helps you manage and deploy capital efficiently with integrated business banking, corporate cards, and automated bill pay.
Investment stages: Seed, Early Stage Venture, Late Stage Venture
Industries of focus: B2B, Enterprise Software, Financial Services, FinTech
Geographical presence: Menlo Park, CA
Founded: 1997
Notable portfolio companies: Talkdesk, Pipedrive, MobileIron, Marketo, Airespace
Portfolio size: Over 278 investments
You can refer to their website here.
4. Mighty Capital
Mighty Capital is an early-growth venture firm in San Francisco that invests with a unique focus on product management. They operate on the belief that strong product leadership is a key driver of success in modern business.
The firm’s product-centric approach is a defining characteristic, and they seek companies where product is at the core of the growth strategy. Their portfolio includes high-profile exits like Airbnb and DigitalOcean, alongside active investments in leaders like Netskope, showing their ability to back companies to public markets and beyond.
This firm is a compelling match if you are a founder with a strong product-led growth model or are building tools for product-focused teams. Their focus on early-growth stages suggests they are best for companies that have already found some market traction and are ready to scale.
Investment stages: Seed, Early Stage Venture
Industries of focus: B2B, Enterprise Software, Product Management
Geographical presence: San Francisco, CA
Founded: 2017
Notable portfolio companies: Airbnb, Amplitude, DigitalOcean, Cameo, Netskope
Portfolio size: 33 investments
You can refer to their website here.
5. Zane Venture Fund
Zane Venture Fund is an Atlanta-based firm that backs early-stage companies with a mission to support "inspirational and overlooked founders." They invest in tech-enabled solutions with a particular focus on the Future of Health.
The firm’s clear commitment to backing underrepresented founders is a core part of its identity, alongside its thematic focus on health, wellness, and education technology. Their portfolio includes companies like MDisrupt, a digital health expert marketplace, and SkillCycle, a workforce development SaaS, showing their interest in B2B models that drive industry change.
This firm is a strong potential partner if you are an early-stage founder from an underrepresented background building a tech company in their target sectors. Once funding is secured, our team at Rho helps you manage and deploy capital efficiently with integrated business banking, corporate cards, and automated bill pay.
Investment stages: Seed, Early Stage Venture
Industries of focus: B2B, EdTech, Health Care, Nutrition, SaaS, Wellness
Geographical presence: Atlanta, GA
Founded: 2019
Notable portfolio companies: MDisrupt, SkillCycle, Freeing Returns, ConConnect
Portfolio size: 20 investments
You can refer to their website here.
6. Branded Hospitality
Branded Hospitality is a New York-based investment firm that supports ventures, solutions, and media companies driving innovation in the hospitality sector. They back businesses that are modernizing how restaurants, bars, and retail establishments operate.
The firm has a clear focus on hospitality tech, with portfolio companies like Bbot, a QR-code payment platform acquired by DoorDash, and PourMyBeer, a self-serve beverage system. This shows their interest in B2B solutions that improve operational efficiency and the customer experience.
This firm is a strong match if you are a founder building technology for the restaurant, retail, or broader hospitality market. Once funding is secured, our team at Rho helps you manage and deploy capital efficiently with integrated business banking, corporate cards, and automated bill pay.
Investment stages: Seed, Early Stage Venture, Private Equity
Industries of focus: Hospitality, Food and Beverage, Retail Technology, SaaS, B2B
Geographical presence: New York, NY
Founded: 2017
Notable portfolio companies: Bbot, PourMyBeer, Ottonomy IO, Chowly
Portfolio size: 73 investments
You can refer to their website here.
7. 2048 Ventures
2048 Ventures is a thesis-driven venture capital firm based in New York that invests in early-stage companies. They focus on backing founders at the pre-seed and seed stages who are building businesses with strong technical foundations.
The firm has a strong focus on companies building differentiated technology in sectors like AI, robotics, and health care. Their portfolio includes a major exit with Aerodome, a drone startup acquired for over $300 million, and successful SaaS companies like GlossGenius and Vitally.
This firm is a good fit if you are a founder at the pre-seed or seed stage with a highly technical or scientific idea. Their track record suggests they are comfortable with complex technologies and can support companies from their earliest days toward significant outcomes.
Investment stages: Seed, Early Stage Venture
Industries of focus: B2B, SaaS, Artificial Intelligence (AI), Robotics, Biotechnology, Health Care
Geographical presence: New York, NY
Founded: 2019
Notable portfolio companies: Aerodome, GlossGenius, Soona, Nomic Bio, Vitally
Portfolio size: Over 136 investments
You can refer to their website here.
8. Golden Section
Based in Houston, Golden Section operates as both a venture capital fund and a founders studio for B2B SaaS companies. They partner with founders at the earliest stages, providing capital alongside hands-on support.
The firm’s "studio" model is a defining characteristic, offering founders direct operational support in product, go-to-market, and operations. This hands-on approach signals their commitment to being a co-builder, not just a financial backer.
Golden Section is a strong fit if you are an early-stage B2B SaaS founder seeking a deeply involved partner to help build your company. Once that partnership helps you secure funding, our team at Rho can help you manage and deploy your new capital with integrated business banking, corporate cards, and automated bill pay.
Investment stages: Seed, Early Stage Venture, Debt
Industries of focus: B2B, SaaS, Software
Geographical presence: Houston, TX
Founded: 2012
Notable portfolio companies: Podsights, Avail, Everwash
Portfolio size: Over 40 investments
You can refer to their website here.
9. Cervin Ventures
Cervin Ventures is a Palo Alto-based firm that invests in early-stage B2B technology companies. Their stated goal is to partner with founders to help build good startups into great companies.
The firm has a strong history of backing companies to successful exits, including acquisitions by major players like PAR Technology and Cornerstone OnDemand. Their portfolio highlights a clear focus on enterprise software, with notable investments like feature management platform LaunchDarkly.
Cervin Ventures is an excellent choice for founders of early-stage B2B software companies who are looking for a partner with a proven ability to guide them toward a major exit. Once you secure that funding, our team at Rho can help you manage and deploy your new capital with integrated business banking, corporate cards, and automated bill pay.
Investment stages: Seed, Early Stage Venture, Late Stage Venture
Industries of focus: B2B, Enterprise Software, Financial Services
Geographical presence: Palo Alto, CA
Founded: 2011
Notable portfolio companies: LaunchDarkly, Punchh, EdCast, Tynker, Celona
Portfolio size: 85 investments
You can refer to their website here.
10. Upekkha Vertical AI Accelerator
Upekkha is an accelerator and venture capital firm that helps Indian founders build global B2B software companies. They provide early-stage backing with a specific focus on SaaS and enterprise software.
The firm's model is built around accelerating Indian SaaS startups for the global stage, with a clear emphasis on AI-powered solutions. Their portfolio includes companies like AI-interviewing platform Talview and skills-assessment tool iMocha, which have raised significant follow-on funding.
Upekkha is an ideal partner if you are an Indian founder at the seed or early stage building a B2B SaaS company with global ambitions. Once you secure funding, our team at Rho can help you manage and deploy your new capital with integrated business banking, corporate cards, and automated bill pay.
Investment stages: Seed, Early Stage Venture
Industries of focus: B2B, SaaS, Enterprise Software, AI
Geographical presence: San Francisco, CA (with a focus on Indian founders)
Founded: 2017
Notable portfolio companies: Spyne, Talview, iMocha, Classpro
Portfolio size: Over 114 investments
You can refer to their website here.
11. Signia Venture Partners
Signia Venture Partners is an early-stage fund in Redwood City that backs founders building impactful companies. They show a flexible approach by investing across multiple stages, from seed rounds to private equity.
The firm has a clear interest in companies with deep technical foundations, particularly in climate and health technology. Their portfolio includes Atmo, an AI weather forecasting company, and Kintsugi, which uses voice biomarkers for mental health screening.
This firm is a strong match if you are an early-stage founder with a highly technical or scientific business idea. Once you secure that funding, our team at Rho can help you manage and deploy your new capital with integrated business banking, corporate cards, and automated bill pay.
Investment stages: Seed, Early Stage Venture, Private Equity, Debt
Industries of focus: B2B, Finance, Climate Tech, Health Tech
Geographical presence: Redwood City, CA
Founded: 2012
Notable portfolio companies: Atmo, Kintsugi, Inertia Systems
Portfolio size: 117 investments
You can refer to their website here.
12. Wildcat Venture Partners
Wildcat Venture Partners, based in San Mateo, invests in early-stage B2B and B2B2C technology companies. They concentrate on sectors like digital health, EdTech, enterprise SaaS, and FinTech.
The firm is defined by its track record of backing companies to major exits, including marketing automation platform Marketo, which was acquired by Adobe. Their portfolio also includes Kabbage, a small-business lending platform purchased by American Express, highlighting their experience in the FinTech space.
Wildcat is a compelling partner for founders with ambitions to build a category-defining company and pursue a large-scale exit. Once you secure that funding, our team at Rho can help you manage and deploy your new capital with integrated business banking, corporate cards, and automated bill pay.
Investment stages: Seed, Early Stage Venture, Late Stage Venture
Industries of focus: B2B, Enterprise SaaS, FinTech, EdTech, Digital Health
Geographical presence: San Mateo, CA
Founded: 2015
Notable portfolio companies: Marketo, Kabbage, Workday, Ticketfly, Rocket Fuel
Portfolio size: 39 investments
You can refer to their website here.
What This Tells Us About The VC Scene for B2B Companies
This overview shows a healthy and balanced funding market for founders building B2B companies. There is strong support at the earliest stages from firms like 2048 Ventures and Zane Venture Fund, while investors such as MissionOG and Wildcat Venture Partners provide capital for growth and later rounds. This indicates that you can find a financial partner regardless of your company's maturity.
Geographically, these firms are not confined to a single hub, with a presence in New York, Philadelphia, and Houston, in addition to Silicon Valley. This broad distribution gives you more options when building your target investor list. Once funding is secured, our team at Rho helps you manage and deploy capital efficiently with integrated business banking, corporate cards, and automated bill pay.
Raise Confidently with Rho
Building a focused list of relevant investors saves you critical time and energy during your fundraise. This guide is designed to help you target the right partners for your business.
When your round closes, our team is ready to support your next steps. Rho can help you set up your financial stack in minutes.
Our platform offers integrated business banking, corporate cards, and automated bill pay, helping you manage and deploy your new capital efficiently.
FAQs about Venture Capital Firms Focused on B2B
What do B2B focused VC firms look for in a startup?
These firms typically seek a clear understanding of your target customer, a strong founding team with relevant industry experience, and evidence of early market traction. A scalable business model is also critical for securing their investment.
Are there many B2B VC firms in Boston?
Yes, Boston has a strong ecosystem of technology-focused venture capital firms. Many invest in B2B software, health tech, and enterprise solutions, making it a key city for founders to consider alongside New York and Silicon Valley.
What is the difference between early stage and late stage venture capital firms?
Early-stage firms invest in companies with initial traction, typically at the Series A or B round, to help them scale. Late-stage firms provide larger capital amounts to mature companies for market expansion or pre-IPO growth.
How do I find the right SaaS VC firms for my company?
Research firms that have invested in your industry and stage. Review their portfolios to see if your company aligns. Attending industry events and building your network can also lead to valuable introductions with relevant software venture capital firms.
How can Rho help after my fundraise?
Once your round closes, you can set up your financial stack with us in minutes. Rho provides integrated business banking, corporate cards, and automated bill pay to help you manage and deploy your new capital efficiently.