14 Top Investors for Series B Funding Every Founder Should Know

Finding the right partners for your early growth or Series B round is a critical step. For many founders, understanding the world of angel investors in Series B can open up new opportunities for capital and mentorship.

Angel investors often operate differently from traditional venture capital firms, sometimes offering more direct involvement and industry-specific guidance based on their own experiences.

To help you identify potential partners, our team at Rho curated this list of top investors for Series B funding. This guide offers a quick overview to help you during your fundraising process.

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What is Series B Angel Investment?

Series B venture capital is typically the second major round of funding for a startup, focused on scaling a business that has already found its product-market fit. Investors at this stage provide capital to help you expand your team, enter new markets, and further develop your product.

Compared to earlier rounds that validate a business idea, Series B is about proving the business model can grow significantly and capture a larger share of the market.

Types of Series B Angel Investors At A Glance

If you're a startup founder raising a Series B round, it helps to know which investors specialize by geography or sector; here's a quick breakdown of those trends across some of the top investors for Series B funding.

Series B Investors in the Bay Area

The San Francisco Bay Area remains a major hub for venture capital. Some of the leading Series B investors for startups in this prolific area include John Locke, Peter Levine, and Patrick Grady.

New York Series B Investors

On the East Coast, New York City is a key center for funding. Among the top investors for Series B funding in New York are Joshua Kushner and William Ford.

BioTech & Health IT Series B Investors

For founders in the life sciences, several investors have experience in this sector. Investors like Paul Walker and Ryan Harris often fund companies in biotechnology and health, while Anders Hove also has a background in the medical and pharmaceutical space.

Series B Investors for SaaS Startups

Many of the best Series B investors in tech have a background in cloud infrastructure and enterprise SaaS. This includes investors such as Matt Murphy, Kevin Harvey, and John Doerr.

Of course, many leading Series B investors to watch invest across a wide range of industries, locations, and even funding stages.

Below is a closer look at some of the top angel investors involved in Series B funding. We've gathered key details about their investment stages and sector interests to show what makes each a notable partner for founders.

1. Paul Walker

Paul Walker is a General Partner at New Enterprise Associates (NEA), where he concentrates on investments in the biopharmaceutical sector. He is recognized for his work with companies in various stages of development, from early clinical trials to commercialization.

Walker shows a strong preference for companies in the biotech, pharmaceutical, and health IT spaces, often participating in both Series A and B rounds. His investment in Allakos's $100M Series B round highlights his involvement in significant growth-stage funding for promising life science startups.

Founders leading biopharma or health tech companies looking for a partner with deep sector knowledge for their Series A or B rounds may find Walker to be a valuable connection. His experience at a major firm like NEA suggests access to a broad network and substantial resources.

• Investment stages: Series A, Series B
• Industries of focus: BioTech, Pharmaceuticals, Health IT, Health & Hospital Services
• Geographical presence: Menlo Park, California
• Ideal investment range: $2.0M - $50.0M, with a sweet spot of $25.0M
• Notable portfolio companies: Allakos, Geron
• Investments count: 20

You can find more information about Paul Walker on his firm's website or Crunchbase profile.

2. John Locke

John Locke is a partner at Accel, where he concentrates on investments in cloud infrastructure, FinTech, and SaaS. Based in the San Francisco Bay Area, he is involved in funding companies from their early seed stages through Series B.

A key aspect of Locke's approach is his continued support for companies across multiple funding rounds. His portfolio includes follow-on investments in companies like SeatGeek and The Zebra, indicating a preference for building long-term relationships with founding teams as they scale.

Founders building enterprise SaaS or consumer internet companies, especially those seeking a partner for the long haul, may find Locke to be a strong fit. His experience suggests he is comfortable backing companies from their initial stages through significant growth.

• Investment stages: Series A, Series B, Seed
• Industries of focus: Cloud Infrastructure, FinTech, Consumer Internet, SaaS
• Geographical presence: San Francisco Bay Area
• Ideal investment range: $15.0M - $70.0M, with a sweet spot of $25.0M
• Notable portfolio companies: SeatGeek, Sysdig, Socure, The Zebra
• Investments count: 25

You can find more information about John Locke on his firm's website or Crunchbase profile.

3. Al Gore

Al Gore, the former U.S. Vice President, is also an angel investor and co-founder of a sustainability-focused investment firm. He is widely known for his work in climate change advocacy, which often shapes his investment decisions in technology companies.

His investment profile shows an interest in both enterprise and consumer internet companies, with participation in Series A and B rounds. A notable characteristic is his smaller check size, which suggests he acts as a strategic angel investor who brings a significant network and public profile to the table.

Founders whose companies have a strong mission, particularly at the intersection of technology and social or environmental impact, may find a valuable partner in Gore. His follow-on investment in Globality indicates a willingness to support companies through multiple stages of growth.

• Investment stages: Series A, Series B
• Industries of focus: Enterprise, Consumer Internet
• Geographical presence: Nashville, Tennessee
• Ideal investment range: $5K - $50K, with a sweet spot of $25K
• Notable portfolio companies: Globality
• Investments count: 6

You can find more information about Al Gore on his website or Crunchbase profile.

4. Joshua Kushner

Joshua Kushner is the founder of Thrive Capital, a well-known venture capital firm based in New York. He is recognized for backing companies across multiple stages, from their early seed rounds through later growth phases.

Kushner has a clear interest in consumer internet, SMB software, and gaming companies. His investment in high-growth businesses like Ramp and Databricks highlights his focus on supporting companies with significant scaling potential.

Founders building consumer-facing technology or software for small businesses may find Kushner to be a good match. His track record of investing from seed to Series B suggests a commitment to supporting companies throughout their entire growth journey.

• Investment stages: Seed, Series A, Series B
• Industries of focus: Consumer Internet, SMB Software, Gaming/eSports
• Geographical presence: New York, New York
• Ideal investment range: $1.0M - $50.0M, with a sweet spot of $25.0M
• Notable portfolio companies: Ramp, Databricks, Isomorphic Labs
• Investments count: 54

You can find more information about Joshua Kushner on his firm's website or Crunchbase profile.

5. Christopher Dean

Christopher Dean is a Managing Director at Summit Partners, a growth equity firm based in Boston. He invests across a wide range of sectors, including FinTech, e-commerce, digital health, and biotech.

His investment history shows a focus on both seed and Series B stages, suggesting a flexible approach to backing companies at different points in their lifecycle. His involvement in Brooklinen's $50M Series B highlights his capacity to support companies through significant growth phases.

Founders in consumer internet, e-commerce, or FinTech who are looking for a partner with experience in scaling businesses could find a good fit with Dean. His broad industry interest suggests an openness to various business models with proven traction.

• Investment stages: Series B, Seed
• Industries of focus: E-commerce, FinTech, Digital Health, Consumer Internet, Education
• Geographical presence: Boston, Massachusetts
• Ideal investment range: $5.0M - $50.0M, with a sweet spot of $20.0M
• Notable portfolio companies: Brooklinen, ShipMonk, Celcoin
• Investments count: 6

You can find more information about Christopher Dean on his firm's website or LinkedIn.

6. Peter Levine

Peter Levine is a general partner at Andreessen Horowitz (a16z), where he primarily invests in enterprise and infrastructure software. He is known for his deep operational background and focus on technically complex companies.

Levine often backs companies from their earliest stages through significant growth, as seen in his long-term support for businesses like Figma and Netlify. His portfolio shows a strong interest in cloud infrastructure, AI, and data services, backing companies that build foundational technology for other developers and businesses.

Founders creating products in the enterprise software or developer tools space could find a valuable partner in Levine. His experience suggests he is a good fit for teams looking for a hands-on investor with a deep understanding of building and scaling technical products.

• Investment stages: Seed, Series A, Series B
• Industries of focus: Cloud Infrastructure, FinTech, Enterprise, BioTech, Data Services, Web3/Crypto, AI
• Geographical presence: Menlo Park, California
• Ideal investment range: $50K - $50.0M, with a sweet spot of $8.0M
• Notable portfolio companies: Figma, Pinecone, Netlify, Labelbox
• Investments count: 71

You can find more information about Peter Levine on his firm's website or LinkedIn.

7. Ryan Harris

Ryan Harris is a General Partner at Norwest Venture Partners, where he brings a unique perspective to investing in the healthcare industry. His background as a medical doctor and researcher at Stanford University School of Medicine heavily influences his investment decisions.

A defining characteristic is his deep clinical expertise, which gives him a specialized ability to assess companies in pharmaceuticals, health IT, and consumer health. He invests in both seed and Series B rounds, indicating he is open to supporting health-focused companies at different points in their growth.

Founders in the health and life sciences sectors may find a valuable partner in Harris. His medical background is especially well-suited for teams that need an investor who understands the clinical and scientific complexities of their product.

• Investment stages: Series B, Seed
• Industries of focus: Pharmaceuticals, Health IT, Consumer Health, Health & Hospital Services
• Geographical presence: San Francisco, California
• Ideal investment range: $1.0M - $30.0M, with a sweet spot of $12.5M
• Notable portfolio companies: Crossover Health, Onsite Dental
• Investments count: 3

You can find more information about Ryan Harris on his firm's website or LinkedIn.

8. John Doerr

John Doerr is a partner at the venture capital firm Kleiner Perkins and a well-known figure in the investment community. He is recognized for backing influential technology companies and has more recently directed his focus toward climate-related innovation.

A key part of his investment approach is a focus on ClimateTech, with portfolio companies like Watershed and Rondo Energy reflecting this priority. He often invests in both Series A and B rounds, suggesting he supports companies as they find their footing and begin to scale.

Founders building companies in ClimateTech, biotech, or cloud infrastructure may find Doerr to be a valuable partner. His role at a major firm like Kleiner Perkins provides access to significant capital and a broad network of industry connections.

• Investment stages: Series A, Series B
• Industries of focus: ClimateTech/CleanTech, Cloud Infrastructure, BioTech, Education
• Geographical presence: Menlo Park, California
• Ideal investment range: $100K - $25.0M, with a sweet spot of $10.0M
• Notable portfolio companies: Watershed, Rondo Energy, Forward
• Investments count: 105

You can find more information about John Doerr on his firm's website or LinkedIn.

9. Matt Murphy

Matt Murphy is a partner at Menlo Ventures, where he invests in enterprise technology. His work often centers on companies building SaaS, AI, and developer tools.

A notable aspect of his investment style is his support for companies across multiple funding rounds, from seed to Series B and beyond. His involvement in companies like Harness and Zylo through several stages suggests an interest in building long-term partnerships.

Founders developing enterprise software, particularly in cloud infrastructure or AI, may find Murphy to be a strong partner. He is a good fit for teams looking for an investor who will stick with them as they scale.

• Investment stages: Seed, Series A, Series B
• Industries of focus: SaaS, AI, Developer Tools, Cloud Infrastructure, Enterprise
• Geographical presence: San Francisco Bay Area
• Ideal investment range: $8.0M - $15.0M, with a sweet spot of $12.0M
• Notable portfolio companies: Harness, Zylo, Vivun, Envoy, Observable
• Investments count: 113

You can find more information about Matt Murphy on his firm's website or LinkedIn.

10. Kevin Harvey

Kevin Harvey is a founder and general partner at Benchmark, one of Silicon Valley's most respected venture capital firms. He is known for backing foundational technology companies and has a long track record of investing in successful startups.

Harvey invests across multiple stages, from seed to Series B, often supporting companies through their entire growth journey. His portfolio shows a strong interest in cloud infrastructure and SaaS, with notable investments in companies like Upwork and Proofpoint.

Founders building businesses in enterprise software, marketplaces, or cloud services may find Harvey to be an excellent partner. His role at Benchmark and history of follow-on funding suggest he is ideal for teams looking for a long-term investor with significant resources.

• Investment stages: Seed, Series A, Series B
• Industries of focus: Cloud Infrastructure, SaaS, Marketplaces, BioTech
• Geographical presence: Menlo Park, California
• Ideal investment range: $1.0M - $15.0M, with a sweet spot of $8.0M
• Notable portfolio companies: Upwork, Proofpoint, Boku
• Investments count: 39

You can find more information about Kevin Harvey on his firm's website or LinkedIn.

11. William Ford

William Ford is the CEO of General Atlantic, a global growth equity firm based in New York. He is known for leading investments across a wide array of industries, from consumer retail to financial technology.

A defining aspect of Ford's investment activity is his focus on the Series B stage. His participation in large private equity deals, such as those with Reliance Retail, signals an interest in well-established companies ready for major expansion.

Founders leading companies in sectors like FinTech, retail, or digital health that require significant capital for scaling may find Ford to be a strong partner. His position at a major firm suggests access to substantial resources and a global network.

• Investment stages: Series B
• Industries of focus: FinTech, Retail, Marketplaces, Digital Health, Consumer Internet
• Geographical presence: New York City
• Ideal investment range: $20.0M - $100.0M, with a sweet spot of $25.0M
• Notable portfolio companies: Reliance Retail, Reliance Jio, IHS Markit
• Investments count: 10

You can find more information about William Ford on his firm's website or LinkedIn.

12. Anders Hove

Anders Hove is an investor and founder of Acorn Bioventures, bringing a deep background in life sciences to his investment work. His experience as a medical doctor, combined with roles at firms like Venrock and Novartis, gives him a unique perspective on the healthcare industry.

A key aspect of Hove's approach is his clinical and scientific expertise, which he applies to companies in biotech, medical devices, and pharmaceuticals. He invests across seed, Series A, and Series B rounds, showing a willingness to support companies from their earliest stages through growth.

Founders with a strong scientific or medical foundation for their business may find Hove to be an ideal partner. His background suggests he can offer valuable guidance on the technical and clinical aspects of product development.

• Investment stages: Series A, Series B, Seed
• Industries of focus: BioTech, Medical Devices, Pharmaceuticals
• Geographical presence: New York, New York
• Ideal investment range: $100K - $5.0M, with a sweet spot of $1.5M
• Notable portfolio companies: Anacor Pharmaceutical, Edge Therapeutics, Intuity Medical
• Investments count: 21

You can find more information about Anders Hove on his firm's website or LinkedIn.

13. Connie Chan

Connie Chan is a Partner at Andreessen Horowitz (a16z), where she heads the consumer sector. She is recognized for her investments in consumer technology, with a particular interest in e-commerce and media companies.

A notable part of her approach is backing companies through multiple growth stages, as seen with her follow-on investments in the marketplace Whatnot. Her background in product management and experience with the Chinese market also inform her investment perspective.

Founders building consumer-facing businesses in e-commerce, AI, or media may find Chan to be a strong match. She is a good fit for teams seeking an investor with operational depth and a global viewpoint.

• Investment stages: Series A, Series B
• Industries of focus: E-commerce, Media/Content, Consumer Internet, AI, Marketplaces
• Geographical presence: Saratoga, California
• Ideal investment range: $500K - $40.0M, with a sweet spot of $20.0M
• Notable portfolio companies: Whatnot, KoBold Metals
• Investments count: 22

You can find more information about Connie Chan on her firm's website or LinkedIn.

14. Patrick Grady

Patrick Grady is a partner at Sequoia Capital, where he focuses on companies building foundational technology. With a background in growth equity, he is known for his work with businesses in cloud infrastructure, AI, and FinTech.

A key part of Grady's approach is his focus on the growth stage, particularly Series B, while also supporting companies through later rounds. His portfolio, which includes companies like Hugging Face and Amplitude, shows an interest in businesses with strong technical foundations and significant scaling potential.

Founders developing enterprise software or AI-driven products who are ready for major expansion may find Grady to be a valuable partner. His experience at a firm like Sequoia suggests he can provide substantial resources for long-term growth.

• Investment stages: Series B
• Industries of focus: Cloud Infrastructure, FinTech, Generative Tech/AI, Enterprise, Consumer Internet
• Geographical presence: Menlo Park, California
• Ideal investment range: $10.0M - $200.0M, with a sweet spot of $25.0M
• Notable portfolio companies: Hugging Face, Amplitude, Cribl, Pilot
• Investments count: 65

You can find more information about Patrick Grady on his firm's website or LinkedIn.

What Startup Founders Should Look for in a Series B Investor

When looking for a Series B investor, it's important to look beyond the capital they provide. The right partner should align with your company's vision and bring relevant experience to the table.

As the investors on our list show, many have specific industry focuses, like SaaS or biotech, or a strong presence in certain regions. This specialization can be a major asset, as it often means they have a network and understanding that can help you scale.

You should also consider their investment style. Some leading Series B investors for startups prefer to invest across multiple funding rounds, offering long-term support. Others may focus specifically on the growth stage, bringing a different kind of expertise.

Ultimately, the process of finding an investor involves researching their portfolio and background to ensure their approach fits your long-term goals. This diligence helps build a partnership that supports your company's growth effectively.

Raise Confidently with Rho

Your time and energy are limited during a fundraise, which makes a focused list of relevant investors invaluable. It allows you to direct your efforts toward building relationships with partners who truly align with your company’s goals.

Once your round is closed, managing that capital becomes the next priority. If you’ve just raised, Rho can help you set up your financial stack in minutes with business banking, corporate cards, and bill pay built for startups.

This setup helps ensure your new angel capital is directed toward growth and operations. Your funding can be put to work efficiently, rather than being lost to manual financial administration.

FAQs about Series B Angel Investors

Who are the top Series B investors outside of NY and the Bay Area?

Many top investors for Series B funding operate in emerging tech hubs. Cities like Austin and Boston have strong venture communities, offering capital and expertise beyond the traditional centers of finance and technology.

Who are the best Series B investors for AI startups?

The best Series B investors in tech often have specific sector experience. For generative AI, look for partners with a background in cloud infrastructure and data services, as they understand the technical challenges of scaling.

How do Series B investors differ from Series A investors?

While Series A investors focus on product-market fit, Series B investors prioritize growth and scaling. They look for proven business models and clear metrics showing you are ready to capture a larger market share.

Which leading Series B investors to watch focus on consumer tech?

Many leading Series B investors to watch have a strong interest in consumer technology. These partners often look for companies with strong brand loyalty and a clear path to scaling their user base effectively.

Who are the top Series B investors for FinTech companies?

Top investors for Series B funding in FinTech often have a background in financial services or enterprise software. They can provide valuable guidance on regulatory issues and scaling financial products to a wider audience.

How can I manage my Series B funding effectively?

Once you close your round, managing capital is key. Rho offers an all-in-one platform with banking, corporate cards, and spend management to help you put your new funding to work efficiently.